Mete IŞIKOĞLU, Ayşenur AVCI, Ayşe KENDIRCİ ÇEVIREN, Batu AYDINURAZ
Journal of the Turkish-German Gynecological Association - 2026;27(1):36-42
Objective: Contrary to international guidelines, intracytoplasmic injection (ICSI) has increasingly been applied to a widening range of indications. The aim of this study is to present our experience with conventional in vitro fertilization (C-IVF) in women in their forties and to contribute to the ongoing debate on whether advanced maternal age should be considered an indication for preferring ICSI. Material and Methods: We analyzed cases of non-male factor infertility in women aged >=40 years. The primary outcome measures were fertilization rate, implantation rate, live birth rate, and miscarriage rate. Results: The cohort included 204 patients with a mean age of 42.30+/-1.97 years, a mean antral follicle count of 4.65+/-2.60, body mass index of 25.80+/-4.54 kg/m2 and a mean duration of infertility of 4.12+/-4.03 years. The mean fertilisation rate was 74.69%. A mean of 1.77+/-0.60 embryos were transferred resulting in an implantation rate, clinical pregnancy rate and live birth rate of 10.44%, 18.62%, 12.25% respectively. Conclusion: Fertilisation, implantation, live birth and miscarriage rates after C-IVF are satisfactory for women >=40 years of age. Given its lower cost, ease of application and comparable clinical outcomes, C-IVF should be considered the preferred method of fertilisation in advanced-age patients.
