SAURABH JHA, SHİV SHANKER TRİPATHİ, RAJİV RATAN SİNGH, SWAGAT MAHAPATRA, UTKARSH KUMAR SRİVASTAVA, SACHİN KUMAR TRİPATHİ, PRADEEP KUMAR YADAV
Comprehensive Medicine - 2025;17(3):159-169
GİRİŞ ve AMAÇ: Acute Compartment Syndrome (ACS) is a serious complication of leg fractures that requires timely diagnosis and intervention. While compartment pressure monitoring remains the gold standard for diagnosis, the role of serum biomarkers as non-invasive diagnostic tools is gaining interest. This study investigates the correlation between serum biomarkers and compartment pressure in diagnosing ACS. To evaluate the Correlation of Serum Biomarkers with Compartment pressure monitoring in suspected acute compartment syndrome in fractures of the leg and its Medicolegal significance. YÖNTEM ve GEREÇLER: This prospective observational study included 60 patients with leg fractures suspected of developing ACS. Serum biomarkers were measured, including creatine kinase, potassium, lactate, bicarbonate, and chloride. Simultaneously, intracompartmental pressure was recorded using a pressure monitoring device. Data were analyzed using descriptive statistics, correlation coefficients, and binary logistic regression to evaluate the association of biomarkers with compartment pressure. BULGULAR: Serum biomarkers, particularly creatine kinase and lactate, offer valuable support in diagnosing Acute Compartment Syndrome (ACS) in leg fractures, complementing compartment pressure monitoring. Integrating these biomarkers into diagnostic protocols can improve early detection, especially in resource-limited settings. This research underscores the medicolegal significance, as accurate ACS identification prevents legal issues arising from delayed intervention and patient harm. TARTIŞMA ve SONUÇ: Incorporating these biomarkers into diagnostic protocols may enhance early detection, particularly in resource-limited settings. Further studies are needed to validate these findings and establish clinical thresholds.This research highlights the medicolegal significance of serum biomarkers in diagnosing Acute Compartment Syndrome (ACS) in leg fractures. Accurate identification of ACS can prevent legal implications related to delayed intervention and patient harm.
