SEMANUR KAYA, İSMET YILMAZ
Anatolian Journal of Pharmaceutical Sciences - 2025;4(1):1-26
:Alzheimer’s Disease (AD) is a progressive and irreversible disease with a high incidence in older people in our country and in the world, and its pathophysiology is not fully understood. There is no definitive treatment for the disease, but some hypotheses that are thought to be effective in treatment have been determined; The most effective of these is the cholinergic hypothesis, and in this hypothesis, it was observed that Acetylcholine (Ach) levels were low in the brains of patients. Other hypotheses are the Tau and Amyloid hypothesis, and oxidative stress and neuroinflammation. Current treatments are more symptomatic, and the first drugs approved for use are the Acetylcholinesterase inhibitor (AchE) rivastigmine, galantamine, donepezil, and the NMDA receptor antagonist memantine. In the development of new treatments, pathological causes have been targeted, new methods have been tried to reduce amyloid accumulation and tau phosphorylation, and effective drugs have been found, but they have not been put into clinical use. Antioxidant compounds have been studied to suppress oxidative stress. Other treatment methods include stem cell therapy, vaccination and the use of estrogen.
