VİVEK B KUTE, MOHAMED RELA, SANJEEV GULATİ, ANİL K BHALLA, GEORGİ ABRAHAM, SANSHRİTİ CHAUHAN, VİNEET MİSHRA, HARİ SHANKAR MESHRAM
Experimental and Clinical Transplantation - 2022;20(12):1058-1068
Objectives: There is no systematic review and metaanalysis for pediatric solid-organ transplants in India. The objective of the study was to collect high-evidence data in this regard. Materials and Methods: A systematic review and metaanalysis was performed for pediatric solid-organ transplants in India. We used the search engines of PubMed, Google Scholar, PubMed Central, Embase, and MEDLINE from beginning of data availability until April 26, 2022. Data from 2 participating centers were also used. Analyses were performed by the DerSimonian random model. Results: Of 50 000 primary searches, only 31 studies were included for analysis. In total, data for pediatric kidney (n = 1057), liver (n = 914), and heart (n = 117) were reported. For the pediatric kidney, the 1-year, 5-year, and 10-year patient survival rates were 96% (range, 93%-99%; I2 = 91.17%, H2 = 11.33, P < .01), 90% (range, 85%-94%; I2 = 93.54%, H2 = 15.47, P < .01), and 75% (range, 62%-88%; I2 = 97.36%, H2 = 37.82, P < .01), respectively. The 1-year, 5-year, and 10-year renal graft survival rates were 93% (range, 90%-96%; I2 = 63.82, H2 = 2.76, P < .01), 83% (range, 76%-89%; I2 = 86.39%, H2 = 7.35, P < .01), and 66% (range, 57%-75%; I2 = 81.68%, H2 = 5.46, P < .01), respectively. The acute rejection rate was 23% (range, 20%-27%; I2 = 5.44%, H2 = 1.06, P = .39). For the pediatric liver transplant, the 1-year and 5-year survival rates were 92% (range, 89%-95%; I2 = 49.96%, H2 = 2, P < .04) and 88% (range, 85-90%; I2 = 0; H2 = 1, P = .72), respectively. Conclusions: The outcomes of pediatric solid-organ transplants in India are comparable to those of the Western world. However, cause of graft loss and patient death is largely attributed to infections, unlike the experiences reported in the West. An effective registry is a primary pillar to expand pediatric solidorgan transplants in India.
