Burcu Aslan CANDIR, Bahar Ulu UNCU, Kubra CITLAK, Esra ATAKUL, Fevzi ALTUNTAS
Experimental and Clinical Transplantation - 2026;24(4):356-358
A 57-year-old woman with relapsed Philadelphia chromosome-negative B-cell acute lymphoblastic leukemia developed diffuse nonblanching erythematous skin lesions following allogeneic hematopoietic stem cell transplant. The lesions appeared concomitantly with hepatic sinusoidal obstruction syndrome and persisted despite engraftment and supportive therapy. Skin biopsy excluded graft-versus-host disease. Upon initiation of defibrotide for moderate hepatic sinusoidal obstruction syndrome, both hepatic and cutaneous findings resolved completely. This case underscores the systemic endothelial-protective potential of defibrotide, extending beyond the hepatic microvasculature, and highlights cutaneous endotheliopathy as a possible manifestation of transplant-associated endothelial injury.
