DİVİJ JAYANT, ARUNANSHU BEHERA, LİLESWAR KAMAN, AJAY SAVLANİA, CHERRİNG TANDUP, KRİSHNA NAİK
Experimental and Clinical Transplantation - 2022;20(10):959-964
Nonvector transmission of dengue virus via organ transplant is rare. We report a probable case of dengue virus transmission via deceased donor liver transplant. The donor was asymptomatic for dengue infection, and the liver recipient developed fever and thrombocytopenia 8 days after transplant. The recipient’s test results were positive for the antigen for nonstructural protein 1 and for immunoglobulin M; however, donor serum samples were not available. Other transplant recipients (renal allograft) also showed dengue-positive test results during the same period, and these patients eventually died. Dengue illness in the liver recipient was severe and associated with shock and cardiomyopathy that required mechanical ventilation, intensive care, and cessation of immunosuppression; however, the patient subsequently improved and was discharged. This case highlights the importance of a high index of suspicion for dengue infection in the presence of graft dysfunction in dengue-endemic areas like India, as well as the importance of the test for the nonstructural protein 1 antigen during dengue outbreaks. These considerations should be included on the standard evaluation of solid-organ transplant donors.
