Merve ERKOÇ, Leyla ÇEVİRME, Hakan BASIR, Reyhan Sevil CANSUNAR, Susamber DİK, Güzin ÖZDEN
Çukurova Anestezi ve Cerrahi Bilimler Dergisi - 2026;9(2):288-295
Objective: Dental procedures are known to be potential triggers for attacks in hereditary angioedema (HAE). Therefore, we aimed to demonstrate the potential of dental procedures to trigger HAE attacks through real-life experiences. Methods: The files of 57 patients diagnosed with HAE-I/II and followed up at the Immunology Allergy Diseases Outpatient Clinic between January 1, 2018, and April 4, 2025, were examined. Results: The study included 44 patients, and short-term prophylaxis (STP) was administered to 27.3%, 26.7%, and 8.3% of those who underwent tooth extraction, filling, and root canal treatment, respectively. The frequency of attacks after tooth extraction was reduced in patients who received STP compared to those who did not receive STP, but this reduction was statistically insignificant (33.3% in those who did not receive STP vs. 22.2% in those who did). When comparing patients who experienced attacks without STP after tooth extraction with those who did not receive STP, it was observed that the group experiencing attacks was predominantly female (p=0.079). Attacks occurring after tooth extraction were not statistically significantly associated with attack triggers. Conclusion: Most HAE patients do not receive STP before dental procedures. Given the risk of fatal laryngeal attacks, albeit rare, it is important to carefully assess patients for their STP needs before dental procedures, and to raise awareness among both patients and dentists regarding the risk of attacks despite STP.
