SONİA DHİMAN, SURENDER VERMA, S K SİNGH
Acta Pharmaceutica Sciencia - 2011;53(2):363-375
The aim of the present research work was to design and develop an optimized mouth dissolving tablet dosage form of an anti-allergic drug, Levocetirizine dihydrochloride. Independent variables such as the amount of subliming agent-camphor (X1) and the amount of superdisintegrant-crospovidone (X2) were optimized using a 2-factor, 3-level Central Composite Design. The dependent variables selected were the disintegration time, wetting time, cumulative % drug release in 10 min. and water absorption ratio of the tablet. The mathematical relationships were generated using multiple linear regression analysis and all the polynomial equations were found to be statistically significant (P<0.0002), as determined using ANOVA.
