HARSHAD KAPARE, SHUBHAM GADGE, NAGESH PATIL, VİNİTA PATOLE, SADHANA RAUT
Acta Pharmaceutica Sciencia - 2025;63(1):2-16
To increase the effectiveness of the anticancer natural product propolis extract (PE), mixed micellar gel formulation composed of Pluronic F127 and Tween 80 was investigated. Cold technique was used to formulate mixed micellar gel loaded with propolis extract (PE-MMG). 32 factorial design was employed to optimize formulation. PE-MMG was characterized for micellar size, surface morphology, surface charge, drug loading, entrapment, release study and in vitro cytotoxicity. Developed optimized formulation showed desirable formulation characteristics Optimized formulation showed desirable characteristics for improved therapeutic performance. Enhanced cytotoxicity potential revealed through MTT Assay by PE-MMG as compared with PE showed enhanced permeability and chemosensitization. In overall developed formulation further studied as a promising carrier for cancer therapy.
