Kiki Jae ESTES-SCHMALZL, Mitchell WOLDEN, Kristin M. LEFEBVRE
Journal of Clinical Practice and Research - 2026;48(1):9-18
Objective: Heart failure with preserved ejection fraction (HFpEF) now accounts for the majority of heart failure cases worldwide, and its prevalence continues to rise. Despite this, diagnosis remains challenging because of substantial patient heterogeneity and the absence of universally accepted diagnostic standards. To address these challenges, the H2FPEF (Heavy, Hypertensive, Atrial Fibrillation, Pulmonary Hypertension, Elderly, and Filling Pressure) and HFA-PEFF (Heart Failure Association-Pre-test Assessment, Echocardiography, and Functional Testing) scoring systems were developed. In this systematic review and meta-analysis, we evaluated the accuracy of these algorithms for identifying HFpEF and their utility in clinical practice.
