KEMAL ŞENER, ADEM ÇAKIR, HÜSEYİN KILAVUZ, SERKAN DOĞAN, RAMAZAN GÜVEN, SEMİH KORKUT
Comprehensive Medicine - 2023;15(2):125-131
INTRODUCTION: Acute cholecystitis (AC) is an acute inflammatory disease of the gallbladder. Although there are algorithms used today in the diagnosis of AC, there is still a need for inexpensive and fast diagnostic parameters. The systemic immune-inflammation index (SIII) is a novel prognostic indicator of systemic inflammation. In our study, the prognostic value of SIII in the differential diagnosis of AC was investigated. METHODS: Our study was designed as a retrospective single-center study. The study was conducted with 150 patients who were admitted to the emergency department with abdominal pain and diagnosed with AC and a control group of 150 patients not diagnosed with AC. Results: In our results, the white blood cell, neutrophil, and C-reactive protein mean values were found to be statistically significantly higher in the study group than in the control group. Once the cutoff value was established at 743.92 (×109 /dL), the SII was found to have a sensitivity of 70% and a specificity of 59.2% in the diagnosis of AC. This assessment was also performed for neutrophil-to-lymphocyte ratio, and with a cutoff value of 2.91, it had a sensitivity of 62% and a specificity of 61.3%. There was no significant relationship between the Gangrenous cholecystitis (GC) and non-GC groups in terms of the diagnostic value of SIII. DISCUSSION AND CONCLUSION: The present study found that the SIII is an index that can be used in the diagnosis of AC but be unsuccessful in distinguishing between GC and non-GC types.
