Mahmut Baran YERLİKAYA, Serhat BİNİCİ, Harun BAYRAM, Ali Rıza KARAYIL, Ozan OKYAY, Fırat ASLAN
Van Medical Journal - 2026;33(4):408-414
Introduction: Accurate preoperative estimation of parathyroid adenoma volume may facilitate surgical planning in patients with primary hyperparathyroidism (PHPT). However, the relationship between biochemical parameters and adenoma size remains controversial. This study aimed to evaluate the association between routinely available preoperative biochemical markers and parathyroid adenoma volume. Materials and Methods: This retrospective single-center study included 61 patients who underwent parathyroidectomy for PHPT between January 2021 and December 2025. Only patients with histopathologically confirmed solitary parathyroid adenoma were included. Preoperative serum parathyroid hormone (PTH), corrected calcium, phosphorus, 25-hydroxyvitamin D, and 24-hour urinary calcium excretion levels were analyzed. Adenoma volume was calculated using pathological specimen measurements. Correlation analyses were performed to assess the relationship between biochemical parameters and adenoma volume. Results: The cohort consisted of 49 females (80.3%) and 12 males (19.7%), with a mean age of 52.8 +/- 14.9 years. Mean adenoma volume was 1.58 +/- 2.00 cm³. Adenoma volume showed a significant positive correlation with preoperative PTH levels (r = 0.33, p = 0.016) and 24-hour urinary calcium excretion (r = 0.29, p = 0.042). In contrast, a significant negative correlation was observed between adenoma volume and serum 25-hydroxyvitamin D levels (r = -0.28, p = 0.047). No significant association was identified between adenoma volume and corrected calcium, phosphorus, or age. Conclusion: Parathyroid adenoma volume demonstrated modest associations with preoperative PTH levels, vitamin D status, and urinary calcium excretion. These routinely available biochemical parameters may provide supportive information for preoperative assessment and operative planning in patients with PHPT.
