Gökşen Görgülü, Emel Doğan Özdaş, Erol Özdaş, Ayşe Taş, Esin Kasap, Tuğba Karadeniz, Muzaffer Sancı
European Journal of Therapeutics - 2025;31(6):455-462
Objective: This research aimed to investigate whether the proportion of the serous carcinoma component influences the prognosis of patients diagnosed with mixed-type endometrial carcinoma. Methods: Based on the relative percentage of the serous component, patients were grouped into two categories: <=50% and >50%. These groups were analyzed and compared with respect to demographic characteristics (age, body mass index, and parity), and histopathological features (grade, level of myometrial invasion, lymphovascular space invasion, tumor size, and FIGO stage). Cox regression and Kaplan-Meier survival analyses were used for the evaluation of overall survival (OS), disease-free survival (DFS), recurrence, and mortality rates. Results: Individuals with a serous component exceeding 50% had significantly reduced DFS and OS (DFS: 42.9 +/- 25.9 vs. 60.2 +/- 25.9 months, p = 0.04; OS: 47.9 +/- 24.8 vs. 68.7 +/- 20.5 months, p = 0.007). Multivariate analysis identified age, deep myometrial invasion, and serous predominance (>50%) as independent predictors of poorer DFS and OS (p < 0.05). Tumor size and lymphovascular space invasion (LVSI) did not have statistically significant correlations with survival outcomes. Conclusion: Although rare, mixed-type endometrial carcinoma with a dominant serous component appears to exhibit more aggressive behavior and poorer survival. The proportion of serous histology should be regarded as a critical prognostic indicator during clinical assessment and treatment planning.
