Pavlo KRAVCHUN, Inna DUNAEVA, Frida LEONTYEVA, Olena POVELICHENKO, Valentyna DIELIEVSKA
Marmara Medical Journal - 2026;39(2):102-109
Objective: Dysmetabolic nephropathies are characterized by disturbances in oxalate, urate and phosphate metabolism and have been suggested as triggering factors for bone and joint pathology. The aim of this study was determine the frequency of dysmetabolic nephropathies in patients with bone and joint pathology and to compare the laboratory parameters between patients with dysmetabolic nephropathy and controls. Patients and Methods: Patients with bone and joint pathology (coxarthrosis, gonarthrosis, ligamentum ruptures, and bone fractures) were enrolled in the study. Dysmetabolic nephropathy (characterized by hyperoxaluria, uraturia or phosphaturia) was revealed in 9% of patients with bone and joint pathology. Sixty-one patients without dysmetabolic nephropathy served as a control group. The patients underwent general clinical and biochemical examinations. Results: The persons with bone and joint pathology and the presence of dysmetabolic nephropathy demonstrated a prevalence of hyperoxaluria (59%) with less frequency of uraturia (25.7%) and phosphaturia (15.1%). Hyperoxaluria was associated with a high incidence of ligamentum ruptures and bone fractures (21.6%). The persons with hyperoxaluria demonstrated higher levels of eosinophils, platelets, white blood cells (WBCs), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), thymol probe, and serum alkaline phosphatase. The persons with dysmetabolic nephropathy showed higher levels of WBCs, ESR, alkaline phosphatase, creatinine, thymol probe, and CRP (P<0.05). Patients with bone fractures demonstrated higher serum levels of glucose, creatinine, CRP and thymol probe and lower levels of serum calcium compared to the controls (P<0.05). Conclusion: Hyperoxaluria was associated with increased frequency of ligamentum ruptures and bone fractures. The physicians should monitor the studied parameters in patients with dysmetabolic nephropathy during the treatment of bone and joint pathology.
