Zeynep KİRİŞCİ, Diğdem TETİK, İrem KAR, Oya TEKELİ
Turkish Journal of Clinical and Experimental Ophthalmology - 2026;21(3):102-112
Purpose: To evaluate optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) parameters in open-angle glaucoma (OAG) and ocular hypertension (OHT) patients using latanoprostene bunod (LBN). Patients and Methods: The study included treatment-naive patients diagnosed with OAG or OHT between June 2023 and May 2024. Intraocular pressure (IOP), OCT and OCTA images were evaluated at baseline, 3 months and 6 months after LBN treatment. Results: The diagnosis was OHT in 40 eyes (83.3%) and OAG in 8 eyes (16.7%). The mean IOP was 25.4+/-5.3 mmHg before and 17.3+/-3.0 and 17.8+/-3.7 mmHg at months 3 and 6 after LBN treatment, respectively (p<0.001 for each visit compared to baseline). No statistically significant difference was observed between baseline and follow-up visits when comparing OCT and OCTA parameters. A moderate positive statistically significant correlation existed between the pre-treatment average ganglion cell layer-inner plexiform layer (GCL-IPL) thickness, minimum GCL-IPL thickness, average retinal nerve fiber layer thickness with the radial peripapillary capillary flux index (RPC-FI) measured at the final examination (r=0.519, p<0.001; r=0.543, p<0.001; r=0.499, p<0.001). Conclusions: In our study, the decrease in IOP was found to be statistically significant, while the changes in OCT and OCTA parameters were not found to be significant. A statistically significant positive correlation existed between the baseline OCT parameters and the final RPC-FI in OCTA. This result may indicate the importance of the RPC-FI in follow-up.
