MELTEM YILMAZ, LEVENT CEM MUTLU
Namık Kemal Medical Journal - 2023;11(1):48-53
Aim: Obstructive sleep apnea syndrome (OSAS) is a common sleep disorder characterized by repeated episodes of apnea and hypopnea during sleep. The repetitive hypoxemic and hypercapnic events can lead to increased proinflammatory cytokine production, endothelial dysfunction, oxidative stress, metabolic dysregulation, and insulin resistance in OSAS patients. In previous studies, some of the hemogram values increased in patients with OSAS and a decrease in these increased values was observed with continuous positive airway pressure (CPAP) treatment. CPAP is the most effective method for treating OSAS and alleviating the patients’ symptoms. The aim of this study was to assess the effect of three-month CPAP therapy on hemocyte profile in people with OSAS. Materials and Methods: Forty patients were included in the study. Data including clinical assessment, full previous polysomnography reports, and baseline and after CPAP therapy, complete blood profile (leukocytes, neutrophils, lymphocytes, hemoglobin, hematocrit, platelets, MPV, PDW, MCV, N/L, and P/L, CRP and fibrinogen) of the participants were collected from the electronic medical record. Results: All patients who completed the study were CPAP compliant (5.53±0.39 h/night). After three months of CPAP treatment, the mean levels of leukocytes, lymphocytes, hemoglobin, hematocrit, MPV, MCV, N/L, and P/L, CRP and fibrinogen were significantly decreased compared to baseline values. Conclusion: Our study showed significant decrease in hemoglobin, hematocrit, leukocyte, lymphocyte, MPV, MCV, N/L, and P/L, CRP and fibrinogen after three-month CPAP therapy.
