JOHN OLUWASOGO AYORINDE, MİCHAEL AYODELE ODENIYI
Acta Pharmaceutica Sciencia - 2021;59(3):461-481
Using the 23(=8) factorial design to determine the effects of excipient modification and process techniques, on mechanical and release properties of tablets containing Enterolobium cyclocarpum gum. Properties of the native (NG), physically modified (PMG) and chemically modified (CMG) gums were evaluated. Metronidazole tablets were prepared from formulations containing NG, PMG, CMG or HPMC. Individual and interacting effects of the parameters were evaluated using the factorial design. Formulations showed drug release of 81 99%. Nature and concentration of polymer, and processing technique (X1, X2 and X3 respectively) had the highest effect on disintegration time. Interaction between X1 and X3 had the greatest effect on the mechanical properties; interaction between X1 and X2 had the greatest effect on drug release. Enterolobium gum produced tablets with high drug release which was sustained for 12 hours. Gum modification and other formulation variables need to be selected to achieve desired formulation objectives.
