GULSEN DOGAN DURDAG, GİZEM BEKTAS, ESENGUL TURKYİLMAZ, HALİME GOKTEPE, MELTEM SONMEZER, YAVUZ EMRE SUKUR, BATUHAN OZMEN, CEM ATABEKOGLU, MURAT SONMEZER
Gynecology Obstetrics & Reproductive Medicine - 2022;28(1):50-55
OBJECTIVE: In frozen-thawed embryo transfer cycles, preparing a synchronous endometrium for the embryo is essential. The aim of this study is to provide individualized luteal support in hormonally replaced frozen-thawed embryo transfer cycles and to evaluate mid-luteal serum progesterone levels and pregnancy outcomes. STUDY DESIGN: In this prospective cohort study, 30 patients were included in a university hospital in a six month period. Serum progesterone level on embryo transfer day was monitored, and if it was found to be below the lower limits defined by previous studies (10 ng/mL), additional 100 mg intramuscular micronized progesterone was administered once. Mid-luteal progesterone levels and pregnancy outcomes were recorded. RESULTS: There was no significant difference between mid-luteal progesterone levels of the patients whose transfer day progesterone was above and below 10 ng/mL (p=0.481). Although the clinical pregnancy rate tended to be higher in patients whose mid-luteal progesterone was above 10 ng/mL, it was also not statistically significant. CONCLUSION: This is the first study in which vaginal progesterone treatment was supported by intramuscular progesterone according to serum progesterone values for the purpose of individualized progesterone support. A significant difference was not found in pregnancy outcomes. However, further studies are required to optimize management and improve pregnancy rates in hormonally treated frozen-thawed embryo transfer cycles.
