Gülşah ALYAR, Fatma Zühal UMUDUM
The Eurasian Journal of Medicine - 2026;58(1):1-5
Background: The aim of the study is to investigate whether long-term calorie restriction and physical activity have an effect on body weight and metabolism in obese individuals with different body mass indexes (BMIs). Methods: Fifty-four obese women who were not receiving any obesity treatment were included in the study. Participants received 12 weeks of low-calorie diet and physical activity training appropriate to their age, gender, and BMI. Body weights were measured at the initial visit and after the intervention. Venous blood samples were collected twice: before and after the intervention. Baseline glucose, insulin, total cholesterol (TC), triglyceride (TG), HbA1c, high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) levels were measured using a Beckman Coulter AU 5800 clinical chemistry autoanalyzer. Results: In the study, insulin and HOMA-IR levels increased significantly as the degree of obesity increased (P < .05). Obese individuals lost an average of 8.6% weight after the combined treatment, and when repeated measurement results were compared, insulin levels in all obese groups decreased significantly (P < .05). HbA1c levels decreased significantly only in moderately obese individuals after the treatment (P < .05). Conclusion: As obesity increased HOMA-IR levels an indicator of insulin resistance increased significantly. Participants lost an average of 8.6% of their weight and insulin levels decreased significantly after the intervention. Long-term lifestyle interventions produced relatively similar effects on metabolism across different obesity levels.
