Kübra BALLI, Nesibe Kahraman ÇETİN, Ferhat ŞİRİNYILDIZ
Experimental Biomedical Research - 2026;9(4):336-347
Aim: To compare the effects of long-term, regular pan-frying with sunflower oil and Ficus carica seed oil on liver and kidney damage in an experimental model. Method: For the experiment, 18 Wistar Albino rats were divided into 3 groups (n=6). The oils were pan fried for 15 minutes. The experimental animals in the Sunflower Oil group were given 3 ml/kg of pan-fried sunflower oil by orogastric gavage for 30 days, and the experimental animals in the Ficus carica Seed Oil group were given 3 ml/kg of pan-fried Ficus carica seed oil by orogastric gavage for 30 days. The rats in the control group were not given fried oil. At the end of the experiment, blood, liver and kidney tissues were taken from the sacrificed rats and biochemical and histopathological evaluations were performed. Results: The oxidative damage and proinflammatory parameters of sunflower oil were significantly higher than the control group. Liver and kidney damages were also higher than Ficus carica seed oil. In both pan fried oil groups, antioxidant levels decreased compared to the control group. In histopathological results, liver degeneration, portal inflammation, focal necrosis and apoptosis, peritoneal necrosis, sinusoidal dilatation and centrilobular necrosis were found to be at lower levels in those applied with Ficus carica compared to the sunflower oil group. Conclusions: It was determined that Ficus carica seed oil caused less damage to the liver and kidney compared to pan-fried sunflower oil. It is recommended to prefer Ficus carica seed oil in pan fried foods.
