MELİSSA LAUB, MATT HARRİS, SCOTT SANOFF, CARL BERG, JENNİFER BYRNS
Experimental and Clinical Transplantation - 2021;19(2):142-148
Objectives: Available data have suggested that directacting antivirals for hepatitis C virus may decrease calcineurin inhibitor concentrations. In this study, our aim was to determine the effects of hepatitis C directacting antivirals on calcineurin inhibitor doses and trough levels. Materials and Methods: This retrospective, singlecenter study included 52 abdominal transplant recipients treated with sofosbuvir-based regimens between 2014 and 2017. The primary outcome was percent change in calcineurin inhibitor troughs and total daily doses between the week before treatment with direct-acting antivirals, days 21 to 35 of treatment, and days 21 to 35 after treatment. Secondary outcomes included sustained virologic response and biopsyproven acute rejection rates. Results: The median percent difference in calcineurin inhibitor troughs from pretreatment to during treatment was -20.5% (interquartile range, -36.2% to 13.1%) and from pretreatment to posttreatment was -13.5% (interquartile range, -33.7% to 10.7%). Corresponding percent changes in calcineurin inhibitor doses were 0% (interquartile range, 0%-0%) and 0% (interquartile range, -10.5% to 33.3%), respectively. Patients on tacrolimus experienced statistically sig - nificant changes in troughs but not doses. During treatment, 65% of patients required no dose change, 23% underwent a dose increase, and 12% had a dose decrease. The sustained virologic response rate was 98%, and the biopsy-proven acute rejection rate was 0%. Conclusions: Hepatitis C direct-acting antiviral therapy may decrease calcineurin inhibitor levels, but this was not associated with clinically different dosing requirements or rejection rates.
