PINAR YILDIZ, ESRA KELES, EGEMEN AYDIN, GAZİ YILDIZ, EMRE MAT, KAZİBE KOYUNCU, REZZAN BERNA BAKİ, ÖZGÜR KARTAL, ALEV ESERCAN, PINAR BİROL, AHMET KALE
Southern Clinics of Istanbul Eurasia - 2023;34(1):25-30
INTRODUCTION: To compare the effect of oral and vaginal micronized progesterone in terms of regularity of menstrual cycle, blood hemoglobin and lipid levels, and endometrial thickness in patients with abnormal uterine bleeding (AUB). METHODS: A total of 80 patients with AUB were randomized into two groups: the oral micronized progesterone group (n=40) and the vaginal micronized progesterone group (n=40). After 3 months of treatment, patients were inquired about compliance to treatment, treatment satisfaction (satisfied-unsatisfied), whether a regular cycle was present, and side effects. Pre- and posttreatment parameters were compared in terms of ultrasonographic endometrial thickness measurement, and hematologic and biochemical parameters. Results: Overall 66 patients, the first group (oral progesterone) and the second group (vaginal progesterone) were evaluated. There was no statistically significant difference between the two groups in terms of age, parity, and body mass index. In both groups, hemoglobin levels were found to be significantly increased after treatment (p=0.0001). No statistically significant intragroup or intergroup difference was found in either group in terms of lipid values before and after treatment. There was a significant decrease in endometrial thickness after treatment in both groups (p=0.0001). After treatment, in the oral progesterone group, the menstrual cycle became regular in 26 (81.25%) patients while in the vaginal progesterone group, it became regular in 30 (88.23%) patients, with no significant difference between groups. In the first group (n=25/32), 78.12% of patients were satisfied with the treatment, whereas in the second group (n=28/34) 82.35% were satisfied with the treatment, with no significant difference between groups. DISCUSSION AND CONCLUSION: Considering its efficacy and safety, easy toleration, and few side effects, vaginal micronized progesterone may be a good alternative to oral preparations in the treatment of AUB.
