Karan LOKHANDE, Dhanashree SANAP, Kisan JADHAV
Journal of Research in Pharmacy - 2025;29(6):2574-2586
The present study aimed to develop a novel drug delivery system utilizing microemulsion as an alternative to traditional oral formulations. This system sought to enhance dissolution rate and thereby improve bioavailability while circumventing first-pass metabolism. To formulate the delivery system, oil was chosen based on drug solubility, while surfactants and co-surfactants (S mix) were selected based on their ability to solubilize the oil and efficiently create microemulsion. The existence ranges of microemulsions were determined through pseudo-ternary phase diagrams, and multiple formulations were developed. The influence of S mix ratio on microemulsion formation and in vitro permeation through a cellophane membrane was investigated. The optimized microemulsion formulations, A7(w/o) and B2(o/w), exhibited globule sizes of 176 nm and 237 nm respectively, with polydispersity indices of 0.02 and 0.14. Additionally, they demonstrated pH values of 5.24 and 5.98, viscosities of 0.809 cp and 0.810 cp, zeta potentials of -30 and 33 mV and conductance values of 47 muS/cm and 166 muS/cm. In vitro drug release for A7 and B2 batches exhibited 71% and 99.5% release respectively. These findings suggested that the developed B2 batch microemulsion holds promise as an alternative for Ondansetron therapy, particularly in mitigating nausea and vomiting induced by cancer medications or radiation therapy.
