EPIDEMIOLOGICAL ANALYSIS OF OBESITY-RELATED COMORBIDITIES AND MORTALITY AMONG POSTMENOPAUSAL WOMEN WITH ENDOMETRIAL CANCER: FINDINGS FROM THE WOMEN'S HEALTH INITIATIVE RANDOMIZED CONTROLLED TRIALS AND OBSERVATIONAL STUDY

Cynthia Thomson, Karen Basen-Engquist, Rogelio Robles-Morales, Denise Roe, Jennifer Erdrich, Britton Trabert, Nazmus Saquib, Michele Cote, Lihong Qi, Dorothy Lane, Tracy Crane

Eurasian Journal of Medicine and Oncology - 2025;9(4):322-330

Department of Health Promotion Sciences, Mel & Enid Zuckerman College of Public Health, University of Arizona, Tucson, Arizona, United States of America

 

Introduction: Obesity is a well-established risk factor for endometrial cancer (EC). Postmenopausal women with EC frequently present with obesity-related comorbidities or develop them after diagnosis, which may impact survival. Objectives: This study aimed to identify modifiable comorbidities (diabetes, cardiovascular disease, hypertension, and fractures) among postmenopausal EC survivors and evaluate the relationship between obesity-related comorbidities and all-cause mortality after an EC diagnosis. Design: Prospective cohort analysis of overall mortality risk in relation to obesity-related comorbidities in women diagnosed with EC.*Corresponding author: Cynthia Thomson (cthomson@arizona.edu)