ANSAM MAHDİ KHALEL , TABARAK SABAH ABBAS, SHATHA HAMEED ALİ, MUSTAFA BASİM ALİ
European Journal of General Dentistry - 2025;14(3):354-360
This study was conducted to determine the periodontal health status and the level of creatine kinase (CK) of the study and control groups and to correlate the level of this enzyme with clinical periodontal parameters in the study and control groups. Materials and Methods This study included 80 male participants aged 35 to 55 years, divided into four groups: poorly controlled type 2 diabetes mellitus with chronic periodontitis (G1), well-controlled type 2 diabetes mellitus with chronic periodontitis (G2), chronic periodontitis without diabetes (G3), and periodontally healthy controls (G4). Clinical periodontal parameters (plaque index, gingival index, periodontal pocket depth [PPD], and clinical attachment loss) and salivary CK levels (measured using enzyme-linked immunosorbent assay) were compared between groups. RESULTS All clinical periodontal parameters and CK levels were highest in poorly controlled type 2 diabetes mellitus with chronic periodontitis patients, and the enzyme level revealed highly significant differences between all pairs of the study and control groups. There were nonsignificant weak correlations of CK with all clinical parameters in all groups except a significant moderate positive correlation with PPD in the nondiabetic with chronic periodontitis group. CONCLUSION It was concluded that poor glycemic control negatively impacts periodontal health status. CK is considered a good biochemical marker of periodontal tissue destruction and is useful in the diagnosis, monitoring, and management of periodontal diseases.
