RAMASAMY MUTHU, AJAY B, ABU FAROQ, KARTHİKEYAN ELUMALAI, KANNAN DIRAVIAM, GNANASEKARAN DHARMALINGAM
Acta Pharmaceutica Sciencia - 2022;60(2):165-177
The present study was designed to investigate the anti-diabetic activity of ethanol extract of Waltheria indica leaves (EEWI) on streptozotocin induced diabetic mice. Effect of EEWI leaves antidiabetic and hypolipidemic effect was evaluated in streptozotocin (55 mg/ kg, i.p ) induced hyperglycaemic mice. EEWI (40 and 100 mg/ kg) was administered orally for 15 days. Glibenclamide (1mg/kg, orally for 15 days) was used as reference standard. The diabetic control animals exhibited a significant decrease in body weight compared with control animals. EEWI inhibited streptozotocin-induced weight loss and significantly alter the lipid levels. Administration of the EEWI caused significant dosedependent reduction in serum glucose, cholesterol, triglyceride and glycosylated haemoglobin % levels in streptozotocin induced hyperglycaemic animals. The ethanol extract of Waltheria indica leaves exhibited antidiabetic activity might be through increased secretion of insulin and, the effect attributed to the presence of flavonoids and phenolic compounds present in extract.
