VİPİN JAIN, RİMPY PAHWA, RASHMİ SHARMA, MUNİSH AHUJA
Acta Pharmaceutica Sciencia - 2024;62(2):423-447
The purpose of the present study is to prepare xanthan films reinforced with nanocellulose and to evaluate them for drug delivery applications using fluconazole as the model drug. The preparation of films by solvent casting method was optimized using a central composite design. It was observed that increasing the concentration of nanocellulose and polyethylene glycol 4000 increases the tensile strength and delays the release of fluconazole from xanthan gum films. The optimal formulation was composed of nanocellulose (100 mg), polyethylene glycol 4000 (50 mg), and xanthan gum (100 mg) which exhibited the tensile strength of 4220 mN and 100% release of the drug over 24 h. The film had a fibrous surface. The film released fluconazole by zero-order kinetics by super case II transport mechanism. It can be concluded based on the present study that reinforcement of nanocellulose in xanthan gum films improves their tensile strength and imparts sustained release character.
