NURULLAH ÇELİK, GÜLŞAH ÜNSAL
Türk Fen ve Sağlık Dergisi - 2023;4(1):1-6
Purpose: There is a conflicting result in terms of insulin resistance (IR) in children with Premature Adrenarche (PA). The study aimed to investigate the IR and Trıglycerıde-Glucose (Ty-G) index in patıents wıth PA. Material and Methods: This cross-sectional study was conducted in a tertiary pediatric endocrinology clinic with 160 children aged 6-8 years old. The study group (n=75) were selected cases diagnosed with PA. Seventy-nine age and sex-matched children were also selected as a control group. Ty-G İndex Homeostasis Model of Insulin Resistance (HOMA-IR), and atherogenic index of plasma (AIP) were calculated. Results: Trıglycerıde-Glucose index, AIP, and HOMA-IR were similar (p>0.05). Ty-G İndex was positively correlated with AIP (r=0.61, p<0.001), BMI-SDS (r=0.26, p=0.002), and HOMA-IR (r=0.33, p<0.001) levels. The DHEA-S level was correlated with the AIP (r=0.24, p=0.005), and BMI-SDS (r=0.17, p=0.03) levels. BMI-SDS was correlated with HOMA-IR (r=0.28, p=0.02) levels. Conclusion: Non-obese children with PA have similar IR parameters compared with control groups. Therefore, additional evaluation for IR parameters in lean children with PA is not required.
