Fatih Han BÖLÜKBAŞI, Ramazan SARI, Erdoğan AYAN, Süheyla Uyar BOZKURT, İlhan ELMACI
Demiroğlu Bilim Üniversitesi Florence Nightingale Tıp Dergisi - 2026;12(2):91-97
Objectives: This study aimed to evaluate the relationship between matrix metalloproteinase-1 (MMP-1) expression and histopathological features, Ki-67 proliferation index, and recurrence in meningiomas. Materials and methods: This retrospective study included 49 patients who underwent surgery for meningioma between January 2003 and December 2006. Archived pathological specimens were re-evaluated for histopathological subtype, World Health Organization (WHO) grade, Ki-67 staining level, and MMP-1 staining characteristics. Age, sex, extent of resection, and recurrence data were obtained from clinical records. Statistical analyses were performed using Student's t-test, chi-square test, Mann-Whitney U test, and Spearman correlation analysis, as appropriate. Results: Forty-nine meningioma cases (16 males, 33 females; mean age: 59.02 +/- 13.96 years; range: 11 to 82 years) met the inclusion criteria. Recurrence was observed in nine of 49 cases (18.4%). Patients with recurrence were significantly younger than those without recurrence (49.67 +/- 6.45 vs. 61.17 +/- 11.68 years, p = 0.024). Recurrence was significantly more frequent in WHO Grade 2 tumors than in Grade 1 tumors (p = 0.026). Subtotal resection was associated with a significantly higher recurrence rate compared with total resection (p = 0.002). Ki-67 level was significantly higher in recurrent cases than in non-recurrent cases (11.05 +/- 12.94 vs. 3.75 +/- 5.31, p = 0.010). However, no significant relationship was found between recurrence and MMP-1 staining extent, staining intensity, or staining level. There was also no significant correlation between MMP-1 staining level and Ki-67 proliferation index (rho = -0.166, p = 0.261). Conclusion: In this series, MMP-1 expression was not associated with recurrence or proliferative activity in meningiomas. In contrast, Ki-67 level, histological grade, and extent of resection were more meaningful predictors of recurrence. Matrix metalloproteinase-1 alone does not appear to be a reliable biomarker for predicting the biological behavior of meningiomas.
