HUSNU TORE YAVUZSEN, ZEKİYE SULTAN ALTUN, GULDEN DİNİZ, DUYGU AYAZ, SEVİL SAYHAN, ILKER CAKİR, BAHADİR SAATLİ, TUGBA YAVUZSEN, SAFİYE AKTAS
Eurasian Journal of Medicine and Oncology - 2022;6(4):299-306
Objectives: The present study aims to evaluate the relationship between microribonucleic acid (miRNA) and target gene expressions with clinical and histopathological data in ovarian cancer. Methods: We evaluated 96 archival samples of paraffin-embedded tissue. Some potentially significant miRNA and target gene expressions were evaluated in different histopathological characteristics. These were quantified using real timepolymerase chain reaction (RTPCR) in tumor and normal tissue. In miRNA expressions, twofold changes are ac cepted as significant. Results: According to histopathological groups, 38 (39.6%) were endometroid adenocarcinoma, 11 (11.5%) were bor derline serous, 29 (30.2%) were serous, and 18 (18.8%) were mucinous carcinoma. When evaluated according to their stages, 26 (27.1%) patients were stage 1A/1B. A relationship was found between miR200a and miR200c and histopatho logic groups, between miR141 and estrogen receptors, between CXCL1 and survival status, and between KEAP1 and ki67. Additionally, miR200a in endometrial and miR200c in mucinous adenocarcinoma were overexpressed. When the relationship between all miRNAs and histopathological groups was evaluated, a significant change was found only in miR200c expression. It was significantly higher in serous than endometrial tumors and significantly higher in mucinous than endometroid tumors. Conclusion: These suggested that miR200a and 200c expressions might be useful for the evaluation of histopathologi cal subgroups of ovarian cancer.
