DELİL ÖZCAN, HAZEL KAYA
Comprehensive Medicine - 2025;17(1):8-12
Objective: This study aimed to quantitatively evaluate changes in the corneal and lenticular structures in vitiligo patients with periocular involvement. Materials and Methods: Thirty patients with vitiligo and periocular involvement, along with 30 healthy volunteers, were included in the study. The anterior segment parameters were evaluated using specular microscopy and corneal topography. To evaluate the corneal endothelium, the mean cell area, mean endothelial cell density, coefficient of variation in the cell area, and central corneal thickness (CCT) were measured using specular microscopy. The mean anterior chamber depth (ACD), mean anterior chamber angle (ACA), mean keratometry (Km), and lens densitometry values were measured using corneal topography, and all parameters were compared between the groups. Results: There were no statistically significant differences in endothelial parameters, CCT, ACD, ACA, and Km values between the vitiligo patients and the control group (p>0.05). Additionally, there was no statistically significant difference in lens densitometry values in any zone between patients with vitiligo and the control group (p>0.05). Conclusion: Our results suggest that anterior segment parameters are not affected in patients with periocular vitiligo, and the pathological destruction seen in melanocytes in vitiligo is not observed in the neural crest-derived cells of the cornea.
