Birtan Yoldaş DOĞAN, Uğur DOĞAN, Hamit Yaşar ELLİDAĞ, Mehmet Nuri KOŞAR
Çukurova Anestezi ve Cerrahi Bilimler Dergisi - 2026;9(1):6-11
Aim: This study aimed to evaluate the changes in serum Orexin A and B levels following laparoscopic sleeve gastrectomy (LSG) in patients with obesity. Methods: Preoperative, postoperative 3rd -, and 6th -month venous blood samples were collected from 30 obese patients diagnosed with obesity and undergoing LSG to measure Orexin A and B levels. The obtained values and body mass indexes (BMI) calculated at the same ti me intervals were compared. Results: A significant reduction in BMI was observed at postoperative 3 and 6 months (p < 0.001). Orexin B levels significantly declined at 6 months compared to preoperative and 3 -month values (p = 0.002), while changes in Orexin A were not statistically significan t. No correlation was found between orexin levels and BMI. Conclusions: Previous experimental studies have shown that orexin peptides are activated in the fasting state and play an active role in obesity by increasing food intake. In this study, we found that Orexin B levels were significantly reduced in patients who experien ced weight loss. We believe that monitoring orexin levels can be beneficial in the treatment of obesity, and inhibiting its activity at the hypothalamic level can contribute to treatment by reducing food intake.
