Bedriye Gizem TEKİN, Esma Gülsun Arslan CELLAT, Suzan TABUR, Seyithan TAYSI
Annals of Clinical and Analytical Medicine - 2026;17(6):561-565
Aim: The objective of this study was to evaluate the relationship between polycystic ovary syndrome and oxidative stress and insulin resistance, to evaluate oxidative stress parameters and serum Fetuin-A levels in polycystic ovary syndrome (PCOS), and to investigate the role of these parameters in PCOS. Methods: The study included 32 PCOS patients and 25 healthy voluntary women with matching age and body mass index. Serum fasting blood glucose, insulin, HbA1c, HDL cholesterol, LDL cholesterol, triglycerides, total cholesterol, malondialdehyde (MDA), peroxynitrite, peroxynitrite, 4-hydroxynonenal, nuclear factor erythroid 2-related factor 2 (NRF 2), Fetuin-A parameters were studied in blood samples obtained from each participant during the early follicular period following 8-10 hours of fasting. Results: Fasting glucose, insulin, HbA1c, HOMA-IR values, which were examined to evaluate carbohydrate metabolism, were found to be significantly higher in the group with PCOS (p<0.05). Triglyceride, total cholesterol, LDL cholesterol, HDL cholesterol levels were found to be significantly higher in the group with PCOS compared to the control group (p<0. 05). MDA, 4 hydroxynonenal levels, which were examined as oxidant substances for oxidative stress assessment, were found to be significantly higher in patients with PCOS compared to the control group (p<0.05). Although peroxynitrite levels, which are among reactive nitrogen species, were found to be higher in the PCOS group compared to the control group, it was not statistically significant (p>0.05). Antioxidant system regulator NRF2 levels were examined and significantly lower NRF2 levels were detected in the PCOS patient group compared to the control group (p<0.05). No difference was detected between the groups in terms of Fetuin A levels (p>0.05). Conclusion: In this study, results supporting the association between PCOS and oxidative stress and insulin resistance were found. Using oxidant and antioxidant markers in the clinical course follow-up and shaping the treatment according to these markers may be beneficial in terms of preventing long-term complications.
