MUSTAFA TUNA, ALPARSLAN YETİŞGİN, MÜSLÜM TOPTAN, ADNAN KİRMİT
Annals of Clinical and Analytical Medicine - 2024;15(11):768-773
Aim: We aimed to examine the relationship between OCT findings and oxidation and antioxidation balance, which is thought to have a role in the etiopathogenesis of the disease in patients with fibromyalgia. Material and methods: A total of 39 female patients with FMS and 41 healthy volunteers were included in the study. Plasma native thiol (NT), total thiol (TT), disulfide (DS), NT/TT, DS/NT, DS/TT, TOS, TAS and OSI values, and eye OCT measurements were evaluated. Regarding OCT measurements, the subfoveal choroid layer, retinal nerve fiber layer, ganglion cell layer, and macular thickness were assessed. Results: When compared to the healthy control group, TAS, TOS, NT, TT, DS levels were high in the FMS patient group (all p<0.05), whereas other measurements were found to be similar (all p >0.05). The increase in TOS levels (p<0.001) in the FMS group was much more significant than the increase in TAS levels (p=0.030). In terms of OCT findings, there was no significant difference between the right and left eye subfoveal choroid thicknesses between the two groups (both <0.001). Discussion: The increase in TOS levels suggests that the level of antioxidants for compensation of increased oxidant status also increases because it is much higher than TAS increase. Since the OSI values are similar, we can state that we did not detect an increase in oxidative stress. We think that FMS patients with high FIQ scores, symptoms, and complaints should be evaluated in terms of oxidative stress and related possible complications.
