EBRAR ALTINALAN, GİZEM GURSOY, EZGİ NAZLI, PAKİZE YIGIT, TUGBA ONDER, YILMAZ CETINKAYA, A ARZU SAYIN SAKUL
Acta Pharmaceutica Sciencia - 2025;63(4):789-804
This study aimed to evaluate the association of serum HMGB-1 and serum P-gp levels with clinical characteristics, seizure patterns, and drug resistance in patients with epilepsy. Patients were divided into monotherapy (n=40) and polytherapy (n=40) groups, and their serum HMGB-1 and serum P-gp levels were analysed using the ELISA technique. In the multinomial logistic regression model, serum P-gp levels were significantly higher in the polytherapy group compared to the healthy control group (p=0.021). Additionally, to the best of our knowledge, this is the first study to analyse the correlation between serum HMGB-1 and serum P-gp levels. In this study, a moderate positive correlation was found between serum HMGB-1 and serum P-gp levels in the monotherapy group of epilepsy patients.
