SALİH DEMİR, MUSTAFA TÖREHAN ASLAN, İLKE ÖZER ASLAN
Annals of Clinical and Analytical Medicine - 2024;15(2):112-116
Aim: Our study aimed to investigate the frequency of anomalies and related maternal and neonatal outcomes in pregnant women who were admitted in our clinic in the last five years and underwent prenatal aneuploidy screening. Materials and Methods: The prenatal fetal aneuploidy screening results of the pregnant women who participated in the study, the pregnant and maternal outcomes of the pregnant women who underwent amniocentesis according to these results, and the detection rates of chromosomal aneuploidy in infants were retrospectively analyzed. Results: According to the first-trimester screening test, 22.4% of the cases (n=121); According to the second-trimester screening test, 11.8% (n=6) of the patients were found to be at high risk for chromosomal aneuploidy. Amniocentesis was recommended to 199 participating in the study, and 17.6% (n=35) of these cases were accepted. Chromosomal aneuploidy was found in 1.8% (n=3) of those who underwent amniocentesis. Two pregnancies with aneuploidy were terminated at the request of the families. The anxiety levels of the pregnant women who had prenatal screening tests were higher in the studies. Discussion: Fetal aneuploidy screening tests may give false positive results at high rates, adversely affecting maternal anxiety and, thus, pregnancy outcomes. To increase the prenatal diagnosis rates cost-effectively, it is helpful to perform combined tests to increase the sensitivity or more sensitive tests are needed.
