Emine Sarcan, Merve Y azla
Journal of Health Sciences and Medicine - 2025;8(6):1041-1048
Aims: This study aimed to evaluate the utility of the MAPH score, a biomarker combining blood viscosity indicators such as mean platelet volume (MPV), total protein, and hematocrit, in differentiating acute ischemic stroke (AIS) from transient ischemic attack (TIA) and predicting major vessel occlusion in patients presenting to the emergency department with suspected stroke. Methods: A retrospective analysis was conducted on 226 patients presenting to the emergency department with focal neurological symptoms. Patients were categorized into AIS and TIA groups based on diffusion-weighted magnetic resonance imaging findings. Data collected included demographic characteristics, vital signs, laboratory parameters, and imaging results. MPV , age, hematocrit, and total protein levels were recorded. High-shear rate and low-shear rate were calculated from total protein and hematocrit values. ROC curve analysis was performed to evaluate diagnostic performance Results: The ROC analysis demonstrated the diagnostic accuracy of the MAPH score in differentiating AIS from TIA and predicting major vessel occlusion. Additionally, the score showed a significant correlation with NIHSS >=20, indicating its association with stroke severity. Conclusion: The MAPH score is a simple and practical tool that aids in distinguishing AIS from TIA and predicting major vessel occlusion, thus improving stroke management in emergency settings.
