NAZLİ KARAMİ, TOHİD KARAMİ, ROGHAYEH AHMADVAND BASMEJANİ, ALİREZA SHAKERİ
European Journal of Geriatrics and Gerontology - 2025;7(2):101-107
OBJECTIVE This study aimed to investigate the prophylactic effect of preoperative ondansetron on the occurrence of postoperative delirium (POD) in older adults who are undergoing orthopedic surgery. Materials and Methods One hundred included patients with American Society of Anesthesiologists (ASA) classification of I and II were randomly divided into two groups: Group A (n=50) and Group B (n=50), who were preoperatively received 2 mL intravenous ondansetron or placebo (saline solution), respectively. Delirium, nausea, itching, and shivering were analyzed between the two groups at 30 minutes, 1, 6, 8, and 24 hours postoperatively. RESULTS There was no significant difference in terms of sex, age, and ASA class of the patients in the two studied groups. Preoperative ondansetron administration has no impact on POD and itching frequency. In addition, no significant relationship between sex and the occurrence of delirium was observed in the ondansetron group. The frequency of shivering at 30 minutes and nausea at 6 and 8 hours in the postoperative period was significantly decreased in the A group compared with the control group. CONCLUSION Ondansetron can still be considered the first line of prevention of postoperative nausea, but does not affect POD, shivering, and itching. However, the study data are not sufficient to draw robust conclusions, and further randomized controlled trials with larger sample sizes are required to validate our results.
