YİGİT MERT BAYRAK, RAMAZAN OZYURT, LEVENT YAŞAR
Annals of Clinical and Analytical Medicine - 2024;15(11):774-779
Aim: The study aims to analyze indicators of systemic inflammation such as platelet-lymphocyte ratio, monocyte-lymphocyte ratio and neutrophil-lymphocyte ratio in patients with hyperemesis gravidarum (HEG). Material and methods: 130 patients diagnosed with HEG according to the criteria of persistent vomiting, ketonuria, electrolyte abnormalities and acid-base disorder constituted the study group. 134 healthy pregnant women, whose age and gestational weeks were matched, constituted the control group. HEG was diagnosed in patients with ketonuria accompanied by a loss of more than 5 percent of their pre-pregnancy weight and vomiting more than three times a day. Both groups were compared in terms of demographic characteristics, hematological parameters and inflammation markers. The relationship between ketonuria severity and inflammation markers of patients in the HEG group was also analyzed. Results: The average age of participants was found to be 8.67±5.72. BMI, parity, and weight of patients in the HEG group were found to be significantly lower than those of controls. HB and hematocrit values of the HEG group were found to be significantly higher than controls (p<0.001). NLO values of patients with 1+ ketonuria were significantly lower than those with 3+ ketonuria (p<0.01). PLO values of patients with 3+ ketonuria were significantly higher than those with 1+ and 2+ ketonuria (p=0.005; p=0.013; p<0.05). MLO measurements of cases with 3+ ketonuria were significantly higher than those with 1+ and 2+ ketonuria. Discussion: The relationship between NLO, MLO, PLO and ketonuria in HEG can be used to monitor the effectiveness of treatment and evaluate the development of complications.
