Yonca ASFUROĞLU, Emine Esra KARACA, Mahmut ASFUROĞLU, Cenk Zeki FİKRET, Özlem Evren KEMER
Experimental and Clinical Transplantation - 2026;24(3):268-273
Objectives: We analyzed prevalence, ocular risk factors, and medical/surgical management of eyes with de novo intraocular pressure elevation following penetrating keratoplasty. Materials and Methods: In this retrospective study, we assessed 400 patients who underwent penetrating keratoplasty from January 2018 to August 2024 for de novo intraocular pressure elevation during the postoperative follow-up period. Results: After exclusion of eyes with preexisting glaucoma, 55 of 400 patients (13.7%) showed intraocular pressure elevation. Postoperatively, mean peak intraocular pressure was 31.92 +/- 6.24 mm Hg. To achieve intraocular pressure control, an average of 2.12 +/- 0.84 topical antiglaucoma medications were administered. Eleven patients (20%) required surgical intervention. Eyes with peripheral anterior synechiae had an increased risk of the need for antiglaucomatous surgery (P = .03; odds ratio 0.175; 95% CI, 0.035-0.868). Conclusions: Eyes with preexisting peripheral anterior synechiae, aphakia and eyes undergoing penetrating keratoplasty for tectonic reasons are more vulnerable to postoperative intraocular pressure elevation/glaucoma.
