Dilara EKİCİ ZİNCİRCİ, Zeynep ERDEM EL, Sevgi ATAR, Esma DEMİRHAN, Ömer KURU, Mehmet ZİNCİRCİ
Forbes Tıp Dergisi - 2026;7(1):39-45
Objective: Adhesive capsulitis (AC) is a painful shoulder condition characterized by progressive restriction of active and passive range of motion. This study aimed to compare the triglyceride-glucose (TyG) index and haematology-derived inflammatory indices between patients with AC and healthy controls and to evaluate their associations with the presence of AC. Methods: In this study, the demographic data, clinical findings and laboratory results of non-diabetic patients with AC were evaluated. Fasting plasma glucose (FPG), lipid profile [triglycerides, high-density lipoprotein (HDL), low-density lipoprotein (LDL), and total cholesterol], C-reactive protein (CRP), vitamins D and B12, and complete blood count, obtained within the preceding 3 months, were recorded. The TyG index, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII) were calculated. Results: Seventy-one participants were included (38 controls and 33 AC). The AC group was older and had higher body mass index (both p<=0.001). FPG (p=0.010), LDL (p=0.001), total cholesterol (p=0.049), and TyG index (p=0.020) were higher in AC, whereas NLR, PLR, SII, CRP, HDL, vitamin D, and B12 were comparable between groups (all p>0.05). In adjusted models, age was a consistent predictor of AC [adjusted odds ratio (aOR) 1.094, 95% confidence interval (CI) 1.036-1.155; p=0.001], and LDL was independently associated with AC (aOR 1.019, 95% CI 1.001-1.037; p=0.044). Conclusion: Non-diabetic AC was associated with metabolic dysregulation, while haematology-derived inflammatory indices remained comparable to controls. Beyond symptomatic management, clinicians should consider screening patients with AC for metabolic dysregulation, as this may aid risk stratification and care.
