JİTENDRA VAGHASİYA, NAVİN SHETH, YAGNİK BHALODİA
Acta Pharmaceutica Sciencia - 2010;52(2):197-204
The present work was designed to investigate the role of Diabetes Mellitus Type-II (DM-II) on renal ischemia reperfusion (I/R)-associated pathophysiology in cardiac damage. DM-II in rats was induced by the administration of nicotinamide (230 mg/kg, i.p.) and streptozotocin (65 mg/kg, i.v.). In vivo renal I/R was performed in both DM-II and normal rats. Lipid peroxidation, xanthine oxidase activity, and nitric oxide levels were significantly increased in cardiac tissue after I/R in diabetic rats compared to I/R in normal rats. Levels of antioxidant enzymes were significantly reduced after I/R in diabetic rats compared to normal rats. Serum TNF-α levels and cardiac tissue myeloperoxidase activity were also significantly increased after I/R in DM-II rats. In conclusion, DM-II rats showed exaggerated cardiac damage by renal I/R injury.
