Sheikh Rakibul ALAM, Najibah NASRIN, Nargis Sultana CHOWDHURY, Romana AKTER, Md Abdur RAHMAN, Rifah Noor CHOWDHURY, Md Rafat TAHSIN, Tasniv Ahsan ARNOB, Niaz MORSHED, Md Sajjad Hossain MIA, F . A. Dain Md OPO, Fahima AKTAR, Md Mahfuz MIAH, Sultan Mehtap BÜYÜKER, Rumman REZA, Muhammad Salehuddin AYUBEE, Md Selim REZA, Jakir Ahmed CHOWDHURY, Abu Asad CHOWDHURY, Shaila KABIR, Md Shah AMRAN
Acta Pharmaceutica Sciencia - 2026;64(2):181-226
Prior research indicated that the whole extract of Crocus sativus exhibited substantial analgesic and anti-inflammatory effects at a dose of 400 mg/kg. We aimed to examine the anti-inflammatory and analgesic activities of a de-oiled, non-resin fraction of C. sativus petals. The 20% n-hexane, 60% ethanol, 20% water extract of de-oiled, non-resin fraction of C. sativus was administered at 100, 200, and 400 mg/kg in rats. Study was conducted in both diabetic and non-diabetic models. The de-oiled, non-resin fraction of C. sativus petal extract imparts significant (p<0.05) anti-inflammatory and analgesic activity at a 200 mg /kg dose, both in diabetic and non-diabetic rats. So, the extract may also contain anti-diabetic compound to ameliorate diabetic condition to demonstrated identical impact both in diabetic and non-diabetic condition. It may be stated that the de-oiled, non-resin fraction of C. sativus is a potent source of analgesic and anti-inflammatory compounds in diabetic and non-diabetic conditions.
