Aslı ODABAŞI GİDEN, Çağrı DOĞAN
Acta Haematologica Oncologica Turcica - 2026;59(2):132-137
Aim: Recurrent pregnancy loss (RPL) affects approximately 1-2% of women of reproductive age and remains a clinically challenging condition with diverse underlying causes. Inherited thrombophilic abnormalities, particularly Factor V Leiden mutation, have been proposed as potential contributors to its pathogenesis; however, the available evidence remains inconclusive. This study aimed to determine the frequency of the Factor V Leiden mutation in women with RPL and to evaluate whether mutation carrier status was associated with the number of previous pregnancy losses within this cohort. The relationships of maternal age, hemoglobin concentration, and fasting blood glucose levels with the number of previous pregnancy losses were investigated. Methods: This retrospective cross-sectional study included 103 women aged 18-45 years who had experienced RPL. Demographic, clinical, laboratory, and genetic data were retrieved from hospital records. Associations between thrombophilia mutations and pregnancy loss were assessed using comparative and correlational analyses, followed by multivariate linear regression to determine independent predictors. Results: Factor V Leiden mutation was identified in 10 patients (9.7%), whereas the Prothrombin G20210A mutation was detected in 5 patients (4.85%). Neither mutation was significantly associated with the number of previous pregnancy losses (p>0.05). Maternal age was significantly positively correlated with the number of previous pregnancy losses (r=0.51, p<0.001). Although fasting blood glucose and hemoglobin levels were associated with the number of previous pregnancy losses in univariate analyses, only hemoglobin and maternal age remained independently associated with the number of previous pregnancy losses after multivariate adjustment (maternal age: B=0.033, standardized beta=0.459, p<0.001; hemoglobin: B=0.112, standardized beta=0.293, p=0.016). Conclusion: Within this cohort of women with RPL, no statistically significant association was observed between Factor V Leiden mutation carrier status and the number of previous pregnancy losses. Maternal age was independently associated with the number of previous pregnancy losses. Larger controlled prospective studies are needed to further clarify the role of inherited thrombophilia in RPL.
