Mesudiye BULUT, Buse HACIOĞLU, Fatih Gökhan AKBAY, Bülent ERDOĞAN, Sara İLERİ, Yusuf OĞUZ, Hadim AKOĞLU
Anatolian Current Medical Journal - 2026;8(3):498-503
Aims: Peritoneal dialysis (PD) is an effective renal replacement therapy; however, technique failure and treatment discontinuation remain major challenges. Identifying modifiable clinical and biological risk factors is essential to improve PD continuity. Methods: This single-center retrospective cohort study included 96 adult PD patients followed between January 2018 and September 2025. Patients were classified into PD continuation and dropout groups, with dropout defined as transition to hemodialysis, mortality, or permanent cessation of PD. Inflammatory indices including Systemic Immune-inflammation Index (SII), Systemic Inflammation Response Index (SIRI), and C-reactive protein-albumin-lymphocyte (CALLY) index were calculated. Comparative analyses were performed, and multivariate logistic regression was used to identify independent predictors. Results: Among 96 patients, 54 continued PD and 31 discontinued treatment. Peritonitis was significantly more frequent in the dropout group, particularly >=2 episodes (p=0.014). Inflammatory markers were markedly elevated in the dropout group (CRP , SII, SIRI; p<0.001), whereas the CALLY index was significantly lower (p<0.001). Multivariate analysis identified recurrent peritonitis, elevated SII and SIRI, and decreased CALLY index as independent predictors of PD discontinuation. Conclusion: PD discontinuation is strongly associated with recurrent peritonitis and increased inflammatory burden. Composite indices such as SII, SIRI, and CALLY may serve as practical tools for risk stratification and improving long-term PD outcomes.
