Neslihan Akanil FENER, Nurcan ÜNVER, Halide Nur ÜRER, Aysu Sinem KOÇ, Gülçehre OĞUZTÜRK, Ekrem Cengiz SEYHAN, Celal Buğra SEZEN
Türk Göğüs Kalp Damar Cerrahisi Dergisi - 2026;34(2):198-206
Background: To examine how pathological variables affect prognosis in patients undergoing surgery for epithelioid pleural mesothelioma (PM). Methods: The study examined 64 patients treated surgery for PM between January 2007 and October 2019, retrospectively. Clinicopathological variables including age, surgical procedure, tumor stage, and detailed histopathological features (nuclear atypia, mitotic count, necrosis, nuclear grading, and tumor grade) were evaluated. Overall survival was analyzed using Kaplan-Meier and Cox proportional hazards regression models. Results: The 5-year survival rate was 8 percent, compared to 62 percent in the first year. Individuals 65 and older had no 5-year survival, whereas patients 65 and younger had a rate of 11 percent (p=0.046). In multivariate analysis, high nuclear grade and high tumor grade were independently associated with worse overall survival. Conclusion: Pathological grading, represented by either nuclear grade or tumor grade, is the strongest independent prognostic factor for survival in patients with epithelioid PM.
