DENİZ IŞIK, OGUZCAN KİNİKOGLU, HEVES SÜRMELİ
Southern Clinics of Istanbul Eurasia - 2024;35(4):311-316
Objective: The localization of colon tumors has prognostic significance. Based on the origin of the primary mass, tumors are classified as right or left colon tumors. During embryological development, right colon tumors (RCC) originate from the mid-gut, while left colon tumors (LCC) originate from the hind-gut. Transverse colon tumors (TCC) account for 10% of all colon tumors. Due to their heterogeneous embryological development, these tumors can behave similarly to either right or left colon tumors. Our knowledge of prognosis is limited due to their inclusion in studies as right colon tumors or exclusion from studies. Our study aims to investigate whether TCC differs from right or left colon tumors by utilizing clinical, pathological, and molecular prognostic factors known to be important in colon cancer, as well as their anatomical localization. Methods: Non-metastatic patients who underwent surgery for transverse colon cancer at our hospital were retrospectively included. Demographic data, pathological features, and treatment status were analyzed. Results: Seventy-six patients with transverse colon tumors who underwent surgery were included in our study. No significant difference was found between recurrence and gender, comorbidity, type of surgery, stage at diagnosis, grade, pathological nodal stage, MSI status, and adjuvant treatment status (p>0.05). However, a significant difference was observed in the relationship between recurrence and histopathological subtype, ECOG, perineural invasion, lymphovascular invasion, and pathological T stage. Multivariable analysis of parameters associated with recurrence revealed that the presence of perineural invasion alone increased recurrence by 25 times and was found to be an independent poor prognostic factor. Conclusion: Perineural invasion was found to be an independent prognostic indicator that predicts recurrence by 25 times in non-metastatic patients with transverse colon tumors. This result can be effectively used in predicting prognosis and making treatment decisions in patients.
