WENXİN ZHANG, BİNGYİ SHİ, HONGJUAN SHİ, JİANLİ WANG, WEİWEİ WANG, ZHAOJİE GUAN, JUN Lİ, XUREN XİAO, YUJİAN NİU, JİNG ZHAO
Experimental and Clinical Transplantation - 2017;15(3):260-266
Objectives: Our objective was to explore factors influencing health-related quality of life in livingdonor kidney transplant recipients. Materials and Methods: A total of 140 kidney transplant recipients, enrolled between December 2014 and April 2015, were administered questionnaires on medical outcomes, 36-item Short Form Health Survey, medical coping modes, cognitive appraisal of health scale, and adverse effects of medications. Path analysis was employed to verify the hypothesized model. Results: Increased serum creatinine level and high economic burden had direct positive effects on negative appraisal (β = 0.18, P< .05 and β = 0.46, P< .01). Adverse effects of medication had direct positive effects on confrontation; whereas negative appraisal had direct positive effect on acceptance-resignation (β = 0.21, P < .05) and direct negative effect on physical com - ponent summary (β = -0.43, P < .001) and mental component summary (β = -0.51, P < .001). In addition, confrontation directly affected mental component summary (β = -0.15, P < .05). The enrolled variables accounted for 25.0% of physical component summary variance and 35.4% of mental component summary variance. Conclusions: In this study, economic burden, serum creatinine levels, and adverse effects of immuno - suppressive therapy were the key external factors, whereas patients’ cognitive appraisal and coping strategies were the main internal factors affecting patients’ health-related quality of life. Medical care providers attending to transplant recipients should be able to identify patients developing negative coping strategies in response to stressors and plan indi - vidualized counseling programs for these patients.
