Dua Fatima SHERWANI, Syeda Abeeha HASAN, Dua Ul KHAIR, Aisha HANIF
Neuropsychiatric Investigation - 2026;64(1):1-2
Folinic acid (leucovorin) is emerging as a potential adjunct in autism spectrum disorder (ASD), driven by growing clinical evidence. A recent pediatric randomized trial by Panda et al, 2024 demonstrated modest subgroup-specific improvements; however, replication remains scarce, and broader applicability uncertain. Given the heterogeneity of ASD, biomarker-based precision and medically supervised caution are crucial.
