REZA GOUDARZI, MOHAMMAD MEHDİ MAHBOOBIAN
Acta Pharmaceutica Sciencia - 2023;61(3):285-302
Atorvastatin (ATR) is a low water-soluble drug with a low oral bioavailability. In the present study, the solid dispersion (SD) technique was used to develop a highsoluble formulation of the ATR by the appropriate carrier and then formulated into a tablet. The atorvastatin solid dispersion (ATR-SD) was developed using the polyvinyl-pyrrolidone K30 (PVP-K30) as a carrier in various ratios by the conventional solvent evaporation method. Dissolution studies were done with the select of the optimum drug:polymer ratio. Tablets were prepared by direct compression using various excipients in different ratios to obtain optimum formulation. The highest dissolution rate was obtained for ATR:PVP-K30 ratio of 1:1, which showed a significant increase in dissolution efficiency after 1 hour. Saturated solubility indicated 1.6-fold enhancement for optimum SD formulation compared to the untreated drug. DSC, XRD, and FTIR analysis proved complete amorphization during SD processes. This study provided a new tablet formulation of ATR with enhanced dissolution characteristics by utilizing the SD technique.
